ArticlePloS one2025
Association between oxidative balance score and systemic immune-inflammation index: NHANES 2003-2018.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association between a composite serum oxidative stress biomarker score and systemic inflammation: A multi-provincial cross-sectional study in Chinese adults.Scientific reports · 2026Observational
- Targeting hypertension through natural phenolics: The multifaceted role of cinnamic acid and its derivatives.Pflugers Archiv : European journal of physiology · 2026Review
- Is Plasma Total Antioxidant Capacity Elevated in Professional Soccer Athletes?: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2026Article
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Authors and funding
4 authors.
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Abstract
backgroundAs we all known oxidative stress and inflammation were interdependent and interconnected. Oxidative balance score (OBS) could assess the antioxidant capacity of an individual's body. The purpose of this study sought to investigate the connection between OBS and the recently proposed inflammatory indicator--Systemic immune-inflammation index (SII).
methodsThe study incorporated 16,080 participants from National Health and Nutrition Examination Survey (NHANES) database (2003-2018). We utilized weight multivariable linear regression analyses to assess this association. Additionally, subgroup analyses and linear relationships were performed for deeper insights. The robustness of the findings was ensured by conducting multiple sensitivity analyses.
resultsIn the multivariate model using the first OBS category as the reference, higher OBS quartiles had a significantly negative association with SII [β = -51.52 (95%CI: -68.31, -34.73), P for trend < 0.001]. The interaction test showed that age (P < 0.001) and hypertension (P = 0.043) had a significant effect on this connection. Restricted cubic splines plot with four knots illustrated a linear relationship between OBS and SII (P-non-liner = 0.677). The findings from the sensitivity analysis aligned with the outcomes of the primary analysis, confirming the consistency and reliability of the results.
conclusionsOBS based on diet and lifestyle had a strongly negative association with SII. This study emphasized the importance of improving an individual's overall antioxidant status through diet and lifestyle changes, highlighting its effectiveness in reducing inflammation index.
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