Observational studyThe Gerontologist2025
A prospective observational study of lucid episodes in advanced dementia.
Observational study in The Gerontologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Data-driven detection of lucid episodes in advanced dementia: Application of latent class analysis to observational data.Journal of Alzheimer's disease : JAD · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
objectivesRecent studies have provided new insights into lucid episodes (LEs) in people living with advanced dementia, but direct observational data documenting LEs are lacking. This prospective observational aimed to detect, characterize, and validate potential LEs. RESEARCH DESIGN AND
methodsData from longitudinal audiovisual observations of participants living with advanced dementia (N = 20) were coded to generate measures of verbal output/expressions and nonverbal communicative actions (e.g., coherence, eye gaze). Potential LEs underwent a structured multi-informant review for validation. We applied generalized estimating equations to compare features of validated LEs to a random 20% sample of participant data used to estimate baseline functioning. Data were fit to a homogeneous Poisson point process to estimate the number of observations needed to accurately estimate the prevalence of LEs.
resultsAcross 539 observations, nine validated LEs were evidenced by three participants (range 2-4). Shared significant differences across LEs included an increased rate of meaningful vocalizations, although heterogeneity in features of LE was observed. DISCUSSION AND IMPLICATIONS: These findings represent the first prospectively documented and directly observed cases of LEs in advanced dementia. Features of LEs vary across individuals, but marked recovery of verbal communication abilities was a defining feature across all events. Lucid episodes occur infrequently, but these findings suggest that they may not be as rare as initially hypothesized. Larger samples and more diverse cohorts are needed to inform robust estimates of incidence and prevalence. Measurement advances to detect and characterize these events are critical to elucidating the underlying mechanisms driving these events and advancing supportive interventions.
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Registered trials
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