Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2025
Feasibility of unsupervised, home-based leg heat therapy in older adults: a pilot, sham-controlled trial.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Plantar Foot Microvascular Reactivity and Oxygenation in Type 2 Diabetes and Peripheral Artery Disease: An Exploratory Study.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.Experimental physiology · 2026Article
- Passive heat intervention research in women: Systematic review and audit of female representation.Experimental physiology · 2026Review
- Effect of repeated hot water immersion on muscle strength, power, function and physical activity in healthy older adults: A randomised crossover trial.Experimental physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Heat therapy (HT) using sauna or hot water immersion can improve cardiovascular and physical function, but these approaches are often impractical for older adults. This pilot, randomized, sham-controlled trial evaluated the feasibility of unsupervised, home-based leg HT using water-circulating trousers in sedentary older adults. Twenty-four participants (mean age: 70 ± 3 yr; 15 women) were randomized to HT (42°C) or sham (33°C) for 90 min daily over 12 wk. Feasibility outcomes included adherence, retention, and safety. Secondary outcomes included 6-min walk distance, sit-to-stand time, plantar flexor strength, MRI-derived muscle morphology, quality of life, and blood pressure. Four participants (two per group) withdrew early due to health status changes or scheduling conflicts. Among those who completed the study, adherence was high (HT: 93 ± 11% and sham: 92 ± 35%). Four HT participants reported minor thermal injuries at the knees, which did not hinder adherence or study participation. There were no significant differences between groups for the secondary outcomes. At 12 wk, the HT group increased their 6-min walk distance by 37.6 m (95% CI: 14.3 to 60.8), compared with 11.5 m (-12.2 to 35.1) in the sham group (group-by-time interaction,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.