Evidence map›Paper›PMID 40748586›Full record

ReviewCell biochemistry and biophysics2025

Therapeutic Potential of Mesenchymal Stem Cells in Psoriasis.

Rebecca Shin Yee Wong, Kien Hui Chua, Ee Wern Tan, Bey Hing Goh

Abstract readReview
In one paragraph

Review in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Hepatoprotective effect of hUC-MSC secretome in LPS-induced HepG2 cells.Iranian journal of basic medical sciences · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rebecca Shin Yee WongDepartment of Medical Education, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, 5, Jalan Universiti, Bandar Sunway, 47500, Petaling Jaya, Selangor, Malaysia. rebeccaw@sunway.edu.my.
Kien Hui ChuaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia.
Ee Wern TanSunway Biofunctional Molecules Discovery Centre, Faculty of Medical and Life Sciences, Sunway University, 5, Jalan Universiti, Bandar Sunway, 47500, Petaling Jaya, Selangor, Malaysia.
Bey Hing GohSunway Biofunctional Molecules Discovery Centre, Faculty of Medical and Life Sciences, Sunway University, 5, Jalan Universiti, Bandar Sunway, 47500, Petaling Jaya, Selangor, Malaysia. goh.beyhing@uts.edu.au.

Funding

Sunway University GRTIN-ECR-SBMDC-05-2024Sunway University GRTIN-RAG-SBMDC-10-2024
6 · The paper itself

Abstract

Psoriasis is a chronic immune-mediated disease mainly affecting the skin with different clinical manifestations. As patients with psoriasis may also suffer from psoriatic arthritis and the skin lesions of psoriasis are disfiguring, their quality of life is often impaired. Many environmental and genetic factors have been implicated in psoriasis development. Currently, there is no cure for the disease and long-term drug treatment is usually necessary, especially in moderate to severe cases. Mesenchymal stem cells (MSCs) are popular candidates for cell-based treatment in many immune-mediated diseases due to their ability to secrete a wide array of cytokines and growth factors and their immunomodulatory properties. MSCs from various sources administered via different routes have been shown to ameliorate psoriasis. This review gives an overview of psoriasis and MSCs and examine preclinical and clinical studies concerning the application of MSCs in the treatment of psoriasis, as well as consolidate major findings in this area of research.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationPsoriasisAnimalsHumansCell-based therapyImmunomodulationMesenchymal stem cellsPsoriasisSecretome

Identifiers

PMID40748586
PMCPMC12680658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.