Observational studyWorld journal of urology2025
Association between major cardiovascular events and abiraterone acetate compared to enzalutamide in patients with metastatic castration-resistant prostate cancer: a post hoc analysis of the EVADE study.
Observational study in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Cardiovascular Complications Associated with Uro-Oncology Treatments-A Primer for the Clinician.Diagnostics (Basel, Switzerland) · 2026Review
- Comment on: "Association between major cardiovascular events and abiraterone acetate compared to enzalutamide in patients with metastatic castration-resistant prostate cancer: a post hoc analysis of the EVADE study" : Name of authors.World journal of urology · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigated the risk of major cardiovascular (CV) events in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone acetate (AA) versus enzalutamide (ENZA); assessed treatments for prostate cancer (PC), focusing on corticosteroid-containing regimens; and examined comorbidities recorded in primary and secondary care.
methodsThis was a post hoc analysis of the retrospective, observational EVADE study in patients who received AA or ENZA for mCRPC. Patient characteristics at treatment initiation were described, focusing on characteristics affecting the risk of CV events, together with PC treatments in the entire PC pathway. Major CV event risk was assessed with Cox regression after adjustment with inverse probability of treatment weighting (IPTW).
resultsOverall, 1,382 patients were included (AA: 556; ENZA: 826). After IPTW adjustment, risk of a major CV event was 65.0% higher in the AA versus the ENZA group (hazard ratio: 1.65; 95% confidence interval: 1.27, 2.14; P = 0.0001). Across the entire patient pathway, the average time on corticosteroid-containing PC regimens was 298 days versus 72 days for the AA versus ENZA group. While type 2 diabetes was less frequently reported in secondary versus primary care (59.8% vs. 94.9%), CV comorbidities were more frequently reported (87.1% vs. 84.2%).
conclusionMajor CV event risk was significantly higher in the AA versus ENZA group, and the AA group had numerically greater exposure to corticosteroid-containing PC regimens over the treatment course. There were discrepancies in recording diabetes and CV comorbidities between primary and secondary care in England.
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