SynthesisNaunyn-Schmiedeberg's archives of pharmacology2026
Intravenous thrombolysis as an adjunct to endovascular thrombectomy in acute basilar artery occlusion: a GRADE-assessed systematic review and meta-analysis.
Synthesis in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Endovascular Therapy Versus Best Medical Treatment in Posterior Cerebral Artery Stroke: A Systematic Review and Meta-Analysis.Brain and behavior · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute basilar artery occlusion (BAO) is a rare but devastating type of ischemic stroke that significantly impacts outcomes. This systematic review and meta-analysis aim to evaluate the efficacy and safety of combining IVT with EVT (EVT + IVT) versus EVT alone in treating acute BAO, focusing on functional independence, mortality, reperfusion success, and hemorrhagic and procedural complications. We conducted a comprehensive search up to May 2025. Effect sizes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs), and statistical significance was determined using p-values. Risk of bias was assessed using the ROBINS-I tool, and certainty of evidence was rated via the GRADE framework. Eight observational studies comprising 5252 patients (1777 EVT + IVT and 3475 EVT alone) were included. The analysis revealed that EVT + IVT showed higher odds of functional independence (mRS 0-2) compared to EVT alone, with an odds ratio of 1.23 (95% CI 1.06-1.43, p = 0.0080). Additionally, EVT + IVT significantly reduced mortality, with an odds ratio of 0.81 (95% CI 0.68-0.96, p = 0.0141). No significant differences were observed in symptomatic intracerebral hemorrhage, subarachnoid hemorrhage, reperfusion success (mTICI 2b/3), or procedural complications. This meta-analysis demonstrates that EVT + IVT is associated with improved functional independence and reduced mortality in acute BAO compared to EVT alone, without increasing the risk of hemorrhagic or procedural complications. These results are, however, based on very low certainty evidence. While bridging therapy appears to provide clinical benefits, high-quality randomized trials are urgently needed to confirm these findings and refine treatment protocols for posterior circulation strokes.
Indexed as
Identifiers
40748475What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.