Trial reportEuropean geriatric medicine2025
Sex differences in health-related quality of life among individuals at high risk of dementia.
Trial report in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeDementia represents an increasing challenge to health systems globally, with a notable impact on health-related quality of life (HRQoL). Nevertheless, the potential effect of sex on the relation between individuals' characteristics and HRQoL, particularly in the early stages of this disease, remains unclear. Therefore, the present study aims to evaluate the association between sociodemographic, lifestyle and health-related factors with HRQoL among individuals at high risk of dementia, according to sex.
methodsThis cross-sectional study was based on baseline data from the MIND-Matosinhos randomized controlled trial, targeting Portuguese adults at high risk of dementia [n = 207; 59.9% female; median age = 70.0 (interquartile range: 11)]. HRQoL was measured using the EQ-5D-5L. The associations between explanatory variables and HRQoL scores (dichotomized by the median) were quantified through odds ratios (OR) and 95% confidence intervals (CI), stratified by sex.
resultsOverall, females reported lower HRQoL when compared with males [median (interquartile range): 0.875 (0.190) vs. 0.923 (0.129); p = 0.004]. Problems in mobility (43.6% vs. 27.7%; p = 0.021), pain/discomfort (71.8% vs. 44.6%; p < 0.001) and anxiety/depression (66.9% vs. 45.8%; p = 0.002), as well as the existence of any problem in five dimensions (7.3% vs. 3.6%; p = 0.004), were more frequently referred by females than males. A stronger association between poorer self-perceived health status and lower HRQoL was observed among females (OR = 8.75, 95% CI:3.64-21.03) compared to males (OR = 1.88, 95% CI:0.72-4.89; p for interaction = 0.020).
conclusionHealth status is associated with HRQoL, distinctively amongst males and females. These findings emphasize the need for sex-specific public health strategies to improve HRQoL in a vulnerable population of individuals at high risk of dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.