Evidence map›Paper›PMID 40748435›Full record

ArticleMolecular neurobiology2025

Formulation and Evaluation of Astaxanthin-Loaded Invasomes as Therapeutic Approaches for Alzheimer's Disease Induced in Rats: Role of SIRT-1/BDNF/miRNA-134/GSK-3β Signaling.

Mohamed A Kandeil, Eman T Mohammed, Marwa A Ibrahim, Rania A Radi, Amr Gamal, Abdel-Razik H Abdel-Razik, Fatma Khalil, Dina Sabry

Abstract read
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed A KandeilDepartment of Biochemistry, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.ORCID http://orcid.org/0000-0003-4993-4042
Eman T MohammedDepartment of Biochemistry, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. eman.ibrahim@vet.bsu.edu.eg.ORCID http://orcid.org/0000-0002-6890-8731
Marwa A IbrahimDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.ORCID http://orcid.org/0000-0001-7935-8379
Rania A RadiDepartment of Biochemistry, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.ORCID http://orcid.org/0000-0003-2063-2809
Amr GamalDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni‑Suef, Egypt.ORCID http://orcid.org/0000-0002-0082-4160
Abdel-Razik H Abdel-RazikDepartment of Histopathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.ORCID http://orcid.org/0000-0002-7982-5827
Fatma KhalilAnimal and Poultry Management and Wealth Development Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.ORCID http://orcid.org/0000-0002-8231-6644
Dina SabryDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Badr University in Cairo, Cairo, 11829, Egypt.ORCID http://orcid.org/0000-0002-6720-3385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive age-dependent neurodegenerative disorder associated with oxidative brain damage, disrupted neuronal transmission, memory loss, and behavioral changes, with aluminum being a key environmental risk factor that exacerbates its effect. The aim of this study is to enhance the therapeutic potential of astaxanthin (AST) in Alzheimer's disease by formulating it into invasomal carriers, with special emphasis on SIRT-1/BDNF/miRNA-134/GSK-3β signaling in an AD-like rat model caused by aluminum chloride (AlCl

Indexed as

Alzheimer DiseaseBrain-Derived Neurotrophic FactorGlycogen Synthase Kinase 3 betaMicroRNAsSignal TransductionSirtuin 1AnimalsMaleOxidative StressRatsRats, WistarXanthophyllsastaxanthineBdnf protein, ratBrain-Derived Neurotrophic FactorGlycogen Synthase Kinase 3 betaMicroRNAsSirtuin 1XanthophyllsAlzheimer’s diseaseAstaxanthin invasomeMiRNA-134NeurotoxicitySIRT-1

Identifiers

PMID40748435
PMCPMC12559087

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.