ArticleJournal of molecular medicine (Berlin, Germany)2025
Adipose-derived mesenchymal stem cells for the prevention of capsular contracture.
Article in Journal of molecular medicine (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effects of Pentoxifylline on Peri-Implant Capsule Cellularity and Thickness: A Controlled Experimental Study in a Rat Silicone Implant Model.International journal of molecular sciences · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsular contracture (CC) is the most common complication associated with implant-based breast surgery, with particularly high risk in patients undergoing alloplastic reconstruction surgery followed by radiation therapy. Revision surgery, the only currently effective treatment, carries a high risk of recurrent CC and secondary complications. This work assessed the prophylactic potential of human adipose-derived mesenchymal stem cells (hAD-MSCs) in a novel animal model of radiation-induced CC. A total of 36 female C57Bl/6 mice were randomly assigned to three groups: (1) IMP (silicone implants only), (2) IMP + RAD (silicone implants and irradiation therapy to promote CC), and (3) IMP + RAD + MSCs (silicone implants, irradiation therapy, and local administration of hAD-MSCs). On day 42 post-implantation, animals were euthanized and capsular tissue was subjected to histological and gene expression analyses. In addition, serum transforming growth factor beta (TGF-β) levels were measured. Targeted radiotherapy induced significant CC. In contrast, on day 42 post-irradiation, the capsular thickness in the IMP + RAD + MSCs group was significantly lower, comparable to that of non-irradiated mice. hAD-MSC treatment also resulted in a significant downregulation of pro-fibrotic and pro-inflammatory genes in the capsular tissue. In this study conducted in a murine model, hAD-MSCs demonstrated significant prophylactic potential in preventing radiation-induced CC. Further research is necessary to investigate the underlying mechanisms and to assess the efficacy and safety of this approach. KEY MESSAGES: Radiotherapy increased capsular thickness and expression of pro-inflammatory and fibrotic genes. Stem cells restored capsular thickness to levels comparable to non-irradiated mice. Stem cells downregulated both pro-fibrotic and pro-inflammatory genes in capsule tissue. Findings highlight the potential of stem cells in preventing radiation-induced capsular contracture.
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