Observational studyPsychopharmacology2026
Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC.
Observational study in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A six-hour time series of the acute effects of ingested cannabis intoxication on a battery of cognitive-motor tasks.PloS one · 2026Article
- Verbal memory dysfunction in substance use and gambling addictive disorders: a comparative analysis of performance accuracy and error typologies.Frontiers in psychology · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studies of the effects of edibles on cognitive function. Further, most studies of cannabis used fixed laboratory doses which may not capture some of the nuances of more naturalistic doses. Delta-9-tetrahydrocannabinol (THC) is the psychoactive component of cannabis yet the relationship of blood THC to cognitive performance is unclear.
methodsIn the present observational study participants (n = 22) were invited to the lab to use their regular legally sourced cannabis edibles. At 150 and 270 min after ingesting the edible, measures of learning and memory (verbal free recall task), executive function (trail making test) and functional vision and visual attention (useful field of view test) were taken. Subjective experiences were also measured, and blood THC was correlated with cognitive outcomes.
resultsAt 150 min after taking a cannabis edible (mean 7.3 ± 2.9 mg of delta-9-tetrahydrocannabinol) decreases were seen in performance on two measures of the verbal free recall. No effects were found on the useful field of view and trail making tests. There were significant increases in subjective experiences as assessed with a visual analog scale and the Addiction Research Centre Inventory; some changes were also seen on the Profile of Mood States. Blood THC was not correlated with any cognitive outcomes.
conclusionsIn sum, the present results suggest that people who choose to use relatively low doses of cannabis edibles may experience decrements in cognitive function while experiencing intoxication.
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