Evidence map›Paper›PMID 40748291›Full record

ArticleJournal of the American Chemical Society2025

Bumps on the Road: The Way to Clean Relaxation Dispersion Magic-Angle Spinning NMR.

Ben P Tatman, Vidhyalakshmi Sridharan, Motilal Uttarkabat, Christopher P Jaroniec, Matthias Ernst, Petra Rovó, Paul Schanda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ben P TatmanInstitute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Vidhyalakshmi SridharanDepartment of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States.
Motilal UttarkabatDepartment of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States.ORCID 0000-0003-4515-9405
Christopher P JaroniecDepartment of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States.
Matthias ErnstInstitute of Molecular Physical Science, ETH Zurich, 8093 Zurich, Switzerland.ORCID 0000-0002-9538-6086
Petra RovóInstitute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.ORCID 0000-0001-8729-7326
Paul SchandaInstitute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.ORCID 0000-0002-9350-7606

Funding

Molecular Mechanisms of Prion and Amyloid PropagationR01GM094357 · NIGMS · OHIO STATE UNIVERSITY · PI JARONIEC, CHRISTOPHER P · 2011 to 2022
$3.2M
800 MHz Solid-State NMR Spectrometer for Biomacromolecular Structure and DynamicsS10OD012303 · OD · OHIO STATE UNIVERSITY · PI JARONIEC, CHRISTOPHER P · 2012 to 2012
$2.0M
Structural and dynamic studies of protein and protein-nucleic acid assemblies in health and diseaseR35GM156238 · NIGMS · OHIO STATE UNIVERSITY · PI Christopher P Jaroniec · 2025 to 2026
$1.1M
NIGMS NIH HHS R01 GM094357NIGMS NIH HHS R35 GM156238NIH HHS S10 OD012303
6 · The paper itself

Abstract

Microsecond-to-millisecond motions are instrumental for many biomolecular functions, including enzymatic activity and ligand binding. Bloch-McConnell Relaxation Dispersion (BMRD) Nuclear Magnetic Resonance (NMR) spectroscopy is a key technique for studying these dynamic processes. While BMRD experiments are routinely used to probe protein motions in solution, the experiment is more demanding in the solid state, where dipolar couplings complicate the spin dynamics. It is believed that high deuteration levels are required and sufficient to obtain accurate and quantitative data. Here we show that even under fast magic-angle spinning and high levels of deuteration artifactual "bumps" in

Indexed as

Nuclear Magnetic Resonance, BiomolecularProteinsNitrogen IsotopesNitrogen IsotopesProteins

Identifiers

PMID40748291
PMCPMC12356580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.