Evidence map›Paper›PMID 40748288›Full record

ArticleACS biomaterials science & engineering2025

Single Polysaccharide Dissolvable Microneedles for Painless Local Anesthesia: Fabrication, Characterization, and

João M S P Leite, Ana C Q Silva, Ana Jesus, Bruna C da Cruz, Sandra I Vieira, Patrícia Dias-Pereira, Paulo C Costa, Isabel F Almeida, Inês Correia-Sá, Armando J D Silvestre and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

João M S P LeiteCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro 3810-193, Portugal.ORCID 0000-0001-9204-0816
Ana C Q SilvaCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro 3810-193, Portugal.
Ana JesusAssociate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal.
Bruna C da CruziBiMED - Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro 3810-193, Portugal.
Sandra I VieiraiBiMED - Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro 3810-193, Portugal.
Patrícia Dias-PereiraICBAS - Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto 4050-313, Portugal.
Paulo C CostaAssociate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal.
Isabel F AlmeidaAssociate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal.
Inês Correia-SáDepartment of Plastic, Reconstructive and Aesthetic Surgery, ULS São João, Porto 4200-319, Portugal.
Armando J D SilvestreCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro 3810-193, Portugal.
Bruno M NevesiBiMED - Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro 3810-193, Portugal.ORCID 0000-0001-7391-3124
Carla VilelaCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro 3810-193, Portugal.ORCID 0000-0002-9212-2704
Carmen S R FreireCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro 3810-193, Portugal.ORCID 0000-0002-6320-4663

Funding

STUDIES IN MATHEMATICS AND STATISTICSZ01CT000024 · CIT · COMPUTER RESEARCH AND TECHNOLOGY · PI WEISS, GEORGE H · 1985 to 2008
$408k
Intramural NIH HHS Z01 CT000024
6 · The paper itself

Abstract

In recent years, microneedles (MNs) have shown high potential as drug delivery devices capable of administering different drugs in a simple, fast, and minimally invasive manner. Their ability to pierce the stratum corneum barrier heavily outweighs the inconveniences posed by conventional administration methods such as hypodermal injections, creams, or ointments. In this work, high-performance, single-component polysaccharide-based microneedles,

Indexed as

Anesthesia, LocalAnesthetics, LocalDrug Delivery SystemsGlucansLidocaineNeedlesAdministration, CutaneousAnimalsCell LineCell SurvivalHumansMiceRAW 264.7 CellsSkinSwineAnesthetics, LocalGlucansLidocainepullulandrug deliverylidocaine, local anesthesiamicroneedlespullulan

Identifiers

PMID40748288
PMCPMC12818717

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.