ArticleDevelopment (Cambridge, England)2025
Myocardin-related transcription factor regulates actomyosin contractility and apical junction remodeling during vertebrate neural tube closure.
Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Genome-Wide Association Studies of Milk Composition Traits in Holstein Cattle Raised in Tropical and Subtropical Conditions.Animals : an open access journal from MDPI · 2026Article
- Genetically engineered ESC-derived embryos reveal Vinculin-dependent force responses required for mammalian neural tube closure.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
Myocardin-related transcription factor A (Mrtfa), also known as megakaryoblastic leukemia protein (Mkl1/MAL), associates with serum response factor (Srf) to regulate transcription in response to actin dynamics; however, the functions of Mrtfa in vertebrate embryos remain largely unknown. Here, we show that Mrtfa is required for neural plate folding in early Xenopus embryos. Mrtfa knockdown reduced F-actin levels and inhibited apical constriction in the neural and non-neural ectoderm. By contrast, overexpression of constitutively active Mrtfa induced apical constriction in ectodermal cells via remodeling of tricellular junctions and junctional recruitment of Myosin II. We also identify potential Mrtfa target genes in embryonic ectoderm that encode actins and many regulators of actomyosin networks and junction remodeling. Our findings suggest a role for Mrtfa in the control of morphogenetic movements during neurulation. We propose that the regulation of actomyosin contractility is an essential cellular response to Mrtfa-dependent transcriptional activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.