Evidence map›Paper›PMID 40748202›Full record

ArticleEpilepsia2025

Association of epilepsy with trajectory of depressive symptoms in late life: The Cardiovascular Health Study.

Hyunmi Choi, Brenna Stepan, Rya Clifton, W T Longstreth, Mitchell S V Elkind, Jose Gutierrez, Evan L Thacker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyunmi ChoiDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0002-0826-2350
Brenna StepanDepartment of Public Health, Brigham Young University, Provo, Utah, USA.
Rya CliftonDepartment of Public Health, Brigham Young University, Provo, Utah, USA.
W T LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, Washington, USA.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0003-2562-1156
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Evan L ThackerDepartment of Public Health, Brigham Young University, Provo, Utah, USA.ORCID https://orcid.org/0000-0002-3813-0885

Funding

Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Effects of vascular risk factors on risk for dementia and stroke after late-onset epilepsy (EpilepsyCOG)R01AG074355 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hyunmi Choi, Evan Lloyd Thacker · 2022 to 2026
$3.9M
Infrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7M
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085083 · HC · UNIVERSITY OF CALIFORNIA DAVIS · PI ROBBINS, JOHN A · 1988 to 1999
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CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
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CENTRAL BLOOD ANALYSIS LABORATORY FOR CHSN01HC085086 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1988 to 2000
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CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
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CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
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CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085081 · HC · JOHNS HOPKINS UNIVERSITY · PI FRIED, LINDA P · 1988 to 2000
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CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · HC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KULLER, LEWIS H · 1988 to 2000
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NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL172803NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG074355NIH HHS R01AG074355
6 · The paper itself

Abstract

objectivesAlthough depression is one of the most common psychiatric comorbidities among individuals with epilepsy, data specific to older adults with epilepsy are scarce. We examined the trajectory of depressive symptom scores in older adults with and without epilepsy.

methodsThe Cardiovascular Health Study is a population-based longitudinal cohort of U.S. adults 65 years of age or older. Depression scores were measured annually using the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) for up to 9 years of follow-up. We used a linear mixed model to estimate mean CESD-10 scores and percent with depression (CESD-10 score ≥10) over time by epilepsy status, adjusted for demographics, health behaviors, clinical characteristics, and measures of life satisfaction.

resultsCESD-10 scores increased at a significantly faster rate over 9 years among older adults with epilepsy (n = 190; 2.8 points) compared to those without epilepsy (n = 5264; 1.8 points; p = 0.005), adjusted for the covariates specified above. The proportion of those who met the threshold for depression also increased at a significantly faster rate among older adults with epilepsy compared to those without epilepsy. The proportion with depression increased by 19.8 cases per 100 (95% confidence interval [CI]: 12.9-26.6) in older adults with epilepsy, compared to an increase of 10.2 cases per 100 (95% CI: 9.0-11.4) in those without epilepsy (a difference in the increase of 9.6 additional cases per 100 [95% CI: 2.7-16.5]; p = 0.007), adjusted for covariates. The association of epilepsy with CESD-10 score trajectory did not differ by sex. SIGNIFICANCE: Older adults with epilepsy experience worse depressive symptom trajectories over time compared to older adults without epilepsy, with one in five individuals experiencing depression over 9 years. These findings highlight the need for systematic and repeated screening of depression in older adults with epilepsy.

Indexed as

DepressionEpilepsyAgedAged, 80 and overCohort StudiesComorbidityFemaleHumansLongitudinal StudiesMalePsychiatric Status Rating ScalesUnited Statesall epilepsy/seizuresdepressionlongitudinal studynatural history studiesolder adultspsychology

Identifiers

PMID40748202
PMCPMC12629636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.