Evidence map›Paper›PMID 40748144›Full record

ArticleJournal of virology2025

Endogenous human herpesviruses 6A/B.

Louis Flamand, Jesse Arbuckle, Pascale Bonnafous, Vincent Descamps, Joshua A Hill, Ruth Jarrett, Keith Jerome, Benedikt B Kaufer, Rie Koide, Anthony L Komaroff and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Louis FlamandDepartment of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Québec, Canada.ORCID 0000-0001-5010-4586
Jesse ArbuckleMolecular Genetics Section, National Institute of Allergy and Infectious iseases, National Institutes of Health, Bethesda, Maryland, USA.
Pascale BonnafousLaboratoire de Virologie, Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Paris, France.
Vincent DescampsService de dermatologie, Hôpital Bichat, AP-HP, Paris, France.
Joshua A HillVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-7665-7100
Ruth JarrettMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Keith JeromeVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Benedikt B KauferInstitute of Virology, Freie Universität Berlin, Berlin, Germany.
Rie KoideGenome Immunobiology RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research and RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Anthony L KomaroffDivision of General Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Peter MedveczkyCollege of Medicine, University of South Florida, Tampa, Florida, USA.
Hiroki MiuraDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Yasuko MoriDivision of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.ORCID 0000-0002-6595-8522
Nicholas ParrishDepartment of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Philip E PellettWayne State University, Detroit, Michigan, USA.ORCID 0000-0002-8536-8343
Michael WoodMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Tetsushi YoshikawaDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Danielle M ZerrSeattle Children's Research Institute, Seattle, Washington, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA-now proposed to be called "endogenous HHV-6A/B (eHHV-6A/B)." Present in 0.2-3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using "eHHV-6A/B" for inherited forms and reserving "chromosomally integrated" for somatic integrations only.

Indexed as

Herpesvirus 6, HumanRoseolovirus InfectionsVirus IntegrationDNA, ViralHumansDNA, ViraleHHV-6endogenous HHV-6HHV-6human herpesvirus 6iciHHV-6inherited chromosomally integrated HHV-6

Identifiers

PMID40748144
PMCPMC12456139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.