Evidence map›Paper›PMID 40748078›Full record

ArticleJournal of clinical microbiology2025

Performance evaluation of plazomicin susceptibility testing of Enterobacterales on VITEK 2 and VITEK 2 Compact Systems.

Edith Csiki-Fejer, Maria Traczewski, Gary W Procop, Thomas E Davis, Meredith Hackel, Gilles Zambardi

Abstract readClinical StudyMulticenter Study
In one paragraph

Article in Journal of clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Edith Csiki-FejerbioMérieux, Inc.Hazelwood, Missouri, USA.ORCID 0009-0001-8910-9648
Maria TraczewskiClinical Microbiology Institute, Inc.Wilsonville, Oregon, USA.
Gary W ProcopCleveland ClinicCleveland, Ohio, USA.ORCID 0000-0002-3164-2968
Thomas E DavisIndiana University School of Medicine IndianapolisIndianapolis, Indiana, USA.
Meredith HackelIHMA Inc.Schaumburg, Illinois, USA.ORCID 0000-0003-3339-2701
Gilles ZambardibioMérieuxLa-Balme-les-Grottes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the present study was to evaluate the VITEK 2 antimicrobial susceptibility test (AST) for Gram-negative (GN) plazomicin performance using the VITEK 2 and VITEK 2 Compact Systems in clinical settings and to demonstrate its equivalence to the Clinical and Laboratory Standards Institute (CLSI) broth microdilution (BMD) technique. The clinical study conducted at four external sites followed the requirements detailed in the US Food and Drug Administration (FDA) and International Standards Organization (ISO) guidance documents and included clinical, challenge, quality, and reproducibility studies. In this multisite study, a total of 979 Enterobacterales isolates were tested. The VITEK 2 card minimum inhibitory concentration (MIC) results were compared with the reference BMD MIC results. The performance following ISO criteria indicated Essential Agreement (EA) = 97.8% and showed that VITEK 2 plazomicin MIC results for Enterobacterales tend to be in exact agreement when compared with the CLSI BMD reference method, except for

Indexed as

Anti-Bacterial AgentsEnterobacteriaceaeSisomicinEnterobacteriaceae InfectionsHumansMicrobial Sensitivity TestsReproducibility of ResultsUnited StatesAnti-Bacterial AgentsplazomicinSisomicinantimicrobial susceptibility testingEnterobacteralesVITEK 2 AST-GN plazomicin

Identifiers

PMID40748078
PMCPMC12421896

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.