ArticleHuman brain mapping2025
Maturation of Hippocampal Subfields in Young Adulthood and Its Relationship With Cognition.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence.bioRxiv : the preprint server for biology · 2026Article
- Maturation of Hippocampal Subfields in Young Adulthood and Its Relationship With Cognition.Human brain mapping · 2025Article
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5 authors.
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Abstract
The hippocampus is a key brain region for memory and cognitive functions, which consists of distinct subregions with different developmental trajectories throughout adolescence. However, trajectories of hippocampal subfield change in young adulthood remain uncharacterized, as is their potential relationship with cortical brain aging and cognitive ability during this time. We conducted two magnetic resonance imaging (MRI) follow-ups of a prenatal birth cohort in young adulthood and studied the effects of chronological age and cortical brain age on the volume of hippocampal subfields in the early 20s (n = 109; 51% men) and late 20s (n = 251; 53% men) and how these age-related volumetric changes might relate to full-scale IQ (FSIQ). We showed that CA1 and CA4DG subfields continue to grow in the third decade of life and that this growth can be observed both at the level of chronological age as well as estimated cortical brain age at both MRI timepoints. Moreover, in men, a larger size of these age-related subfields was associated with higher FSIQ, and the deviations between cortical brain age and chronological age mediated the relationships between right CA1 and FSIQ, as well as right CA4DG and FSIQ. These findings reveal that coordinated patterns of advanced cortical brain aging and hippocampal maturation may confer a cognitive advantage in young adulthood.
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