Evidence map›Paper›PMID 40747870›Full record

ArticleGlia2025

Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice.

Sasikarn Looprasertkul, Reiji Yamazaki, Yasuyuki Osanai, Nobuhiko Ohno

Abstract read
In one paragraph

Article in Glia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Senotherapeutics for Brain Aging Management.Neurology international · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sasikarn LooprasertkulDepartment of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, Shimotsuke, Japan.ORCID 0009-0005-5361-4844
Reiji YamazakiDepartment of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, Shimotsuke, Japan.ORCID 0000-0001-8052-6624
Yasuyuki OsanaiDepartment of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, Shimotsuke, Japan.ORCID 0000-0001-7285-7546
Nobuhiko OhnoDepartment of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, Shimotsuke, Japan.ORCID 0000-0002-6536-2753

Funding

Japan Multiple Sclerosis SocietyJapan Society for the Promotion of Science 20KK0170Japan Society for the Promotion of Science 21H04786Japan Society for the Promotion of Science 21H05241Japan Society for the Promotion of Science 21K15197Japan Society for the Promotion of Science 23K14432Japan Society for the Promotion of Science 24H00583Japan Society for the Promotion of Science 25K02967Jichi Medical UniversityKobayashi FoundationNational Center of Neurology and Psychiatry 3-5Takeda Science Foundation
6 · The paper itself

Abstract

The activity of oligodendrocyte progenitor cells (OPCs) and oligodendrocytes (OLs) throughout life drives myelination, which is crucial for rapid neuronal communication. OLs in the aging brain demonstrate a reduced capacity for myelin formation and maintenance, but the underlying differentiation of individual OLs and morphological changes of their myelin in aging remain unclear. Here, we utilized Pdgfra-CreER

Indexed as

AgingCorpus CallosumMyelin SheathOligodendrogliaAnimalsCell DifferentiationMiceMice, Inbred C57BLMice, TransgenicReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor alphaagingcorpus callosummyelinationnewly generated oligodendrocyteoligodendrocyte

Identifiers

PMID40747870
PMCPMC12436990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.