Evidence map›Paper›PMID 40747867›Full record

ArticleThe journal of obstetrics and gynaecology research2025

Sertoli cell tumor associated with ovarian sex cord tumor with annular tubules in a patient with 46 XY disorder of sex development and 9p24.3 deletion, case report.

Tabatha Petrillo, Christian Battipaglia, Elisa Semprini, Cinzia Baldessari, Marta Pirola, Olga Calabrese, Antonino Farulla, Giliana Ternelli, Albino Eccher, Laura Botticelli and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tabatha PetrilloDivision of Obstetrics and Gynaecology, AUSL of Modena, Carpi, Italy.
Christian BattipagliaDepartment of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.ORCID https://orcid.org/0009-0000-1563-7598
Elisa SempriniDepartment of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Cinzia BaldessariDepartment of Oncology and Hematology, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
Marta PirolaDepartment of Oncology and Hematology, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
Olga CalabreseMedical Genetic Unit, University Hospital of Modena, Modena, Italy.
Antonino FarullaDepartment of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Giliana TernelliDepartment of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.
Albino EccherDepartment of Pathology, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Laura BotticelliDepartment of Pathology, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Alessandro D GenazzaniDepartment of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case involving a 22-year-old phenotypically female patient who presented to our care with primary amenorrhea and spontaneous breast development. Hormonal analysis indicated hypergonadotropic hypogonadism, and imaging revealed a hypoplastic uterus and calcified ovaries. Karyotyping was 46, XY and the presence of the SRY gene was confirmed. The patient underwent laparoscopic bilateral salpingo-oophorectomy due to the high risk of malignancy development. Histopathological analysis revealed bilateral Sertoli cell tumors and a sex cord tumor with annular tubules in the right gonad. Next generation sequencing genetic testing identified a 1.24 Mb deletion on chromosome 9p24.3, which included the DMRT1, DMRT2, and DMRT3 genes, as well as a partial deletion of KANK1. Hormonal replacement therapy was not initiated due to the potential risk of tumor recurrence, and follow-up imaging was scheduled every 6 months for the first 2 years and then annually. No recurrence was observed at 24 months.

Indexed as

Disorder of Sex Development, 46,XYOvarian NeoplasmsSertoli Cell TumorSex Cord-Gonadal Stromal TumorsChromosomes, Human, Pair 9FemaleHumansYoung Adult9p24.3 deletiondisorder of sex developmentprimary amenorrheaSertoli cell tumorsex cord tumor with annular tubules

Identifiers

PMID40747867
PMCPMC12315508

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.