ReviewJournal of leukocyte biology2025
Posttranslational sialylation and its impact on neutrophil recruitment.
Review in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Neutrophils are essential components of the innate immune system, playing a critical role in responding to infections and inflammation. Their recruitment from blood circulation to affected tissues follows a well-coordinated multistep adhesion and activation cascade. Recent studies highlight the importance of posttranslational modifications, particularly sialylation, in regulating neutrophil recruitment. Sialic acids, negatively charged monosaccharides, are attached to glycoproteins and glycolipids on neutrophil surfaces, influencing their stability, signaling, and interactions with endothelial cells. Selectins, key mediators of neutrophil rolling, recognize sialylated ligands such as sialyl Lewis-X on the neutrophil surface enabling the initial capture and rolling process. Additionally, sialylation of chemokine receptors and integrins modulate neutrophil activation and firm adhesion. Beyond recruitment, sialylation affects neutrophil homeostasis, aging, and clearance, as well as their interactions with pathogens and tumor cells. Dysregulation of sialylation has been linked to autoimmune diseases, cancer progression, and infections, making it an interesting target for therapeutic interventions. This review focuses on the functional role of posttranslational sialylation in neutrophil biology, detailing its impact on leukocyte recruitment, immune modulation, and potential therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.