ArticleAnnals of medicine2025
Global, regional, and national trends in colorectal cancer from 2010 to 2021: an analysis of the global burden of disease study 2021.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of Node-RADS for lymph node metastasis in rectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Extracellular Vesicles Drive Invasive Characteristics and Matrix Remodelling in Organotypic Models of Colorectal Cancer Progression.Journal of extracellular biology · 2026Article
- Pathology-derived clinical micro-architectural diagnostics of tumour-microbiome interactions in colorectal cancer.Journal of translational medicine · 2026Article
- Trends in MASLD-related cirrhosis and liver cancer across diverse populations, 2010-2023.Hepatology international · 2026Article
- Chemotherapeutic Loading and Delivery of Patient-Derived Extracellular Vesicles Are Influenced by Colorectal Cancer Disease Stage and Protein Corona.Pharmaceutics · 2026Article
- Prognostic value of lymphovascular invasion and CEA for cancer-specific survival in octogenarian colorectal cancer patients.World journal of surgical oncology · 2026Article
- Gender disparities in the global burden of nasopharyngeal carcinoma: persistence and evolution of male predominance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Analysis of ovarian cancer burden among reproductive-aged women and its association with the socio-demographic index from 1990 to 2021.World journal of surgical oncology · 2026Article
- Addressing colorectal cancer screening gaps in Uruguay: a health literacy perspective.Cancer causes & control : CCC · 2026Article
- Nitidine chloride suppresses polo-like kinase 1 via MYCN-associated transcriptional regulation in colorectal cancer: a multi-omics and spatial transcriptomics study.Frontiers in oncology · 2026Article
- Quantitative ctDNA Profiling ofInternational journal of molecular sciences · 2025Article
- Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing.BMC gastroenterology · 2025Article
- The paradigm shift: re-evaluating preclinical animal models for colorectal cancer in the precision medicine era.Frontiers in immunology · 2025Review
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5 authors.
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Abstract
backgroundColorectal cancer (CRC) is a major global health challenge due to its high incidence and mortality rates. Understanding its epidemiological trends is essential for informing prevention and intervention strategies.
methodsThis study analyzed global, regional, and national CRC data from 2010 to 2021, focusing on age-standardized incidence, mortality, disability-adjusted life years (DALY), and associated risk factors. Data was sourced from the Global Burden of Disease (GBD) Study 2021 and stratified by the Sociodemographic Index (SDI).
resultsGlobally, CRC incidence increased by 35.91% from 1,614,410 cases in 2010 to 2,194,143 cases in 2021. The mortality rate decreased from 13.37 per 100,000 in 2010 to 12.40 per 100,000 in 2021. DALY increased by 23.94%, yet the age-standardized DALY rate (ASDR) decreased by 6.88%. Notably, high SDI regions showed a downward trend in incidence and mortality, while high-middle SDI regions experienced increasing incidence but decreasing mortality. In 2021, the highest incidence was in the Netherlands (69.80 per 100,000), and the highest mortality was in Uruguay (27.46 per 100,000). Dietary and metabolic risk factors significantly contributed to CRC burden across all SDI levels.
conclusionThe study reveals a complex epidemiological landscape of CRC, marked by rising incidence but declining mortality globally. These findings highlight the urgent need for targeted public health interventions, particularly in high-risk regions and younger populations, focusing on modifiable lifestyle and socioeconomic factors. Continuous monitoring and tailored prevention strategies are critical to reducing the global burden of CRC.
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