Evidence map›Paper›PMID 40747785›Full record

ArticleeLife2025

Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state.

Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran and 10 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The Anterior BNST Is Required for Novelty-Driven Social Interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
  6. How dopamine guides our social world.Pharmacological reviews · 2025
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Christopher R Lee *Salk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0002-5952-9924
Gillian A Matthews *Salk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0001-6754-0333
Mackenzie E Lemieux *Salk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0001-6015-8668
Elizabeth M WasserleinThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.
Matilde BorioSalk Institute for Biological Studies, La Jolla, United States.
Raymundo L MirandaSalk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0009-0009-9694-1545
Laurel R KeyesSalk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0001-5433-9948
Gates P SchneiderSalk Institute for Biological Studies, La Jolla, United States.
Caroline JiaSalk Institute for Biological Studies, La Jolla, United States.
Andrea TranSalk Institute for Biological Studies, La Jolla, United States.
Faith AloboudiSalk Institute for Biological Studies, La Jolla, United States.
May G ChanSalk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0009-0005-6664-3521
Enzo PeroniThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.
Grace PereiraThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID https://orcid.org/0000-0003-4371-7020
Alba López-MoragaThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID https://orcid.org/0000-0002-2084-4855
Anna PalléSalk Institute for Biological Studies, La Jolla, United States.
Eyal Y KimchiThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID https://orcid.org/0000-0003-4327-1102
Nancy Padilla-CoreanoSalk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0001-9293-2697
Romy WichmannSalk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0002-4506-8813
Kay M TyeSalk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0002-2435-0182

Funding

Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social GroupsDP1AT009925 · NCCIH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TYE, KAY MAXINE · 2017 to 2021
$6.4M
Solving the Valence Assignment ProblemR37MH102441 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Kay Maxine Tye · 2021 to 2026
$5.6M
A Novel Strategy for Combating Obesity: Reprogramming Neural CircuitsDP2DK102256 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TYE, KAY MAXINE · 2013 to 2018
$2.7M
Exploring neural circuit mechanisms of social contact and social isolationR01MH115920 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TYE, KAY MAXINE · 2018 to 2022
$2.4M
Charles A. King Trust Postdoctoral Research FellowshipJohnson and Johnson Summer ScholarshipMassachusetts Institute of Technology Brains & Cognitive Sciences DepartmentNational Science Foundation CCF-1231216NCCIH NIH HHS DP1 AT009925NIDDK NIH HHS DP2 DK102256NIH HHS DP1-AT009925 (NCCIH)NIH HHS DP2-DK102256 (NIDDK)NIH HHS R01-MH115920 (NIMH)NIH HHS R37-MH102441 (NIMH)NIMH NIH HHS R01 MH115920NIMH NIH HHS R37 MH102441
6 · The paper itself

Abstract

Affiliative social connections facilitate well-being and survival in numerous species. Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However, the identity, interconnectivity, and functional encoding of social information within these circuits remains poorly understood. Here, we focus on downstream projections of dorsal raphe nucleus (DRN) dopamine neurons (DRN

Indexed as

Dopaminergic NeuronsDorsal Raphe NucleusLonelinessAnimalsDopamineMaleMiceMice, Inbred C57BLNeural PathwaysSocial BehaviorDopamineamygdaladopaminedorsal raphe nucleuslonelinessmouseneurosciencesocialvalence

Identifiers

PMID40747785
PMCPMC12316461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.