Evidence map›Paper›PMID 40747766›Full record

ArticleEpigenomics2025

Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos.

Sarina Abrishamcar, Jasmine K Aqua, Christian Dye, Rebecca Jones-Antwi, Yinxian Chen, Linda C Gallo, Maria M Llabre, Krista M Perreira, Martha L Daviglus, Maria Argos and 8 more

Abstract read
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In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sarina AbrishamcarDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0001-9478-7374
Jasmine K AquaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-4226-8748
Christian DyeDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.ORCID 0000-0003-4532-7042
Rebecca Jones-AntwiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0001-5237-5785
Yinxian ChenDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, CA, USA.ORCID 0000-0002-3678-5888
Maria M LlabreDepartment of Psychology, University of Miami, Miami, FL, USA.
Krista M PerreiraDepartment of Social Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC,USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois Chicago, Chicago, IL, USA.
Maria ArgosDepartment of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.ORCID 0000-0003-4234-252X
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Anke HülsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6005-417X
Andrea BaccarelliDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID 0000-0002-3436-0640
Jianwen CaiDepartment of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0003-2700-9593
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Karen N ConneelyDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-1994-6934
Shakira F SugliaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-5634-9290

Funding

Social Stress Epigenetics and Cardio-Metabolic Health Among LatinosR01MD013320 · NIMHD · EMORY UNIVERSITY · PI SUGLIA, SHAKIRA FRANCO · 2019 to 2023
$3.1M
NIMHD NIH HHS R01 MD013320
6 · The paper itself

Abstract

backgroundHispanics/Latinos in the United States experience disproportionately high psychosocial factors compared to non-Hispanic/Latino Whites. Psychosocial factors may accelerate biological aging, measured by epigenetic age acceleration (EAA), a DNA methylation biomarker predictive of morbidity and mortality.

methodsWe investigated the cumulative impact of psychosocial factors on EAA over time in 922 adults from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Psychosocial exposure profiles were derived using self-organizing maps (SOM), an unsupervised clustering method. We calculated EAA from whole blood DNA methylation at two timepoints using GrimAge and DunedinPACE.

resultsSOM identified four clusters: Cluster 1 (

conclusionsThese findings highlight the cumulative impact of psychosocial factors on EAA and how stressors can get "under the skin" and contribute to health disparities.

Indexed as

AgingDNA MethylationEpigenesis, GeneticHispanic or LatinoStress, PsychologicalAdultAgedFemaleHumansMaleMiddle AgedUnited StatesDNA methylation ageDunedinPACEepigenetic age accelerationGrimAgeHispanic/Latino healthlongitudinalPsychosocial factorsself-organizing maps

Identifiers

PMID40747766
PMCPMC12369621

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.