ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Neurovascular coupling and functional connectivity changes through the Alzheimer's disease spectrum: Effects of simvastatin treatment.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Simvastatin rescues cognitive impairment in an AβNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A cerebrospinal fluid blood-brain barrier dysfunction score is associated with progression from mild cognitive impairment to Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Effects of a Red-Ginger-Based Multi-Nutrient Supplement on Optic Nerve Head Blood Flow in Open-Angle Glaucoma.Nutrients · 2026Article
- Microvascular dysfunction and aberrant network activity drive reduced brain oxygenation in a mouse tauopathy model.Research square · 2025Article
- Neurovascular coupling and functional connectivity changes through the Alzheimer's disease spectrum: Effects of simvastatin treatment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
introductionAlzheimer's disease (AD) is a leading cause of dementia, with vascular dysfunction being an early pathogenic event. Cardiovascular interventions show therapeutic promise, hence may improve neurovascular coupling (NVC) and resting-state functional connectivity (RSFC) hemodynamic responses.
methodsNVC and RSFC were recorded longitudinally in control and AD transgenic mice treated or not with simvastatin (SV) using optical imaging of intrinsic signals (OIS), together with memory testing.
resultsAD mice showed early decreases in NVC and bilateral connectivity (BC) in motor and cingulate cortex, and hypoconnectivity within the sensory-motor network. Early default-mode network (DMN) hyperconnectivity was followed by hypoconnectivity, together with a decreased BC in somatosensory (S) cortex. SV restored NVC, prevented aberrant DMN hyperconnectivity, improved BC of S, and preserved memory. DISCUSSION: Our results indicate that OIS can detect early AD-related changes in NVC and RSFC, and that a preventive cardiovascular strategy may bear therapeutic promise in at-risk individuals. HIGHLIGHTS: Optical imaging of intrinsic signals captures Alzheimer's disease (AD) progression and response to therapy. Neurovascular coupling (NVC) and resting-state functional connectivity (RSFC) disruptions precede memory decline in AD transgenic mice. Simvastatin prevented NVC and AD-specific RSFC disruptions and protected memory. This study supports translational value of hemodynamic signal in early AD detection.
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