ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2025
Mannose-binding lectin insufficiency is associated with airway Haemophilus colonization and a higher risk of post-RSV bronchiolitis recurrent wheezing.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Construction and validation of a predictive model for recurrent wheezing risk within one year after initial hospitalization for RSV lower respiratory tract infection in preschool children.Frontiers in pediatrics · 2026Article
- Mannose-binding lectin insufficiency is associated with airway Haemophilus colonization and a higher risk of post-RSV bronchiolitis recurrent wheezing.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
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9 authors.
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Abstract
objectiveTo investigate whether mannose-binding lectin (MBL) insufficiency influences the airway microbiota composition and development of subsequent recurrent wheezing in infants with severe respiratory syncytial virus (RSV) bronchiolitis.
methodsSixty-seven infants who were hospitalized during an initial episode of severe RSV bronchiolitis at 6 months of age or less were included in the study and followed up until the age of 3 years. Serum and sputum samples were collected. The serum MBL concentrations were determined by ELISA; the sputum microbiota and cytokines were analyzed by 16S rRNA-based sequencing and multiplex immunoassay, respectively.
resultsTwenty-six infants developed recurrent wheezing by the age of 3 years, and 41 did not. The rate of MBL insufficiency was significantly higher among infants who developed recurrent wheezing compared to those who did not [50.0% (13/26) vs. 24.4% (10/41), (p = .031)]. MBL insufficiency was independently associated with a higher risk of subsequent development of recurrent wheezing (adjusted Odds Ratio: 3.5, 95% CI 1.1-12.3, p = .035). Haemophilus was found to be the most discriminative genus between infants with and without MBL insufficiency (LDA >4.0). The level of INF-γ (p = .019) in infants with MBL insufficiency was significantly lower than that among infants with normal MBL.
conclusionDuring the first episode of severe RSV bronchiolitis in infants <6 months of age, MBL insufficiency was associated with a higher risk of developing subsequent recurrent wheezing by age three. Infants with MBL insufficiency were more likely to be colonized with Haemophilus and have weaker airway IFN-γ response.
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