Evidence map›Paper›PMID 40747539›Full record

ArticleStroke2025

Diminished Cerebral Oxygen Extraction and Metabolic Rate in Neonates With Hypoxic Ischemic Encephalopathy.

Dengrong Jiang, W Christopher Golden, Zhiyi Hu, Sandrine Yazbek, Aylin Tekes, Shuo Chen, Wen Shi, Yifan Gou, Jennifer Shepard, Fulden Aycan and 6 more

Abstract read
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dengrong JiangThe Russell H. Morgan Department of Radiology and Radiological Science (D.J., A.T., H.L.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-3843-1020
W Christopher GoldenDepartment of Pediatrics (W.C.G., J.S., C.P., F.J.N.), Johns Hopkins University School of Medicine, Baltimore, MD.
Zhiyi HuDepartment of Biomedical Engineering (Z.H., W.S., Y.G., H.L.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0009-0002-6222-8126
Sandrine YazbekDepartment of Diagnostic Radiology and Nuclear Medicine (S.Y., P.L.), University of Maryland School of Medicine, Baltimore.ORCID 0000-0002-5557-7371
Aylin TekesThe Russell H. Morgan Department of Radiology and Radiological Science (D.J., A.T., H.L.), Johns Hopkins University School of Medicine, Baltimore, MD.
Shuo ChenDepartment of Psychiatry (S.C.), University of Maryland School of Medicine, Baltimore.ORCID 0000-0002-7990-4947
Wen ShiDepartment of Biomedical Engineering (Z.H., W.S., Y.G., H.L.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-5312-4889
Yifan GouDepartment of Biomedical Engineering (Z.H., W.S., Y.G., H.L.), Johns Hopkins University School of Medicine, Baltimore, MD.
Jennifer ShepardDepartment of Pediatrics (W.C.G., J.S., C.P., F.J.N.), Johns Hopkins University School of Medicine, Baltimore, MD.
Fulden AycanDepartment of Pediatrics (F.A., D.E.-M.), University of Maryland School of Medicine, Baltimore.
Charlamaine ParkinsonDepartment of Pediatrics (W.C.G., J.S., C.P., F.J.N.), Johns Hopkins University School of Medicine, Baltimore, MD.
Lina F ChalakDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas (L.F.C.).
Hanzhang LuThe Russell H. Morgan Department of Radiology and Radiological Science (D.J., A.T., H.L.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-3871-1564
Frances J NorthingtonDepartment of Pediatrics (W.C.G., J.S., C.P., F.J.N.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-4557-2646
Dina El-MetwallyDepartment of Pediatrics (F.A., D.E.-M.), University of Maryland School of Medicine, Baltimore.ORCID 0000-0003-1394-6789
Peiying LiuDepartment of Diagnostic Radiology and Nuclear Medicine (S.Y., P.L.), University of Maryland School of Medicine, Baltimore.ORCID 0000-0003-0830-5960

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
A Novel Wavelet Neurovascular Bundle for Real Time Detection of Injury in Neonatal EncephalopathyR01NS102617 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LINA F CHALAK · 2017 to 2026
$4.0M
An integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7M
Assessment of Brain Oxygen Consumption in Neonates using MRIR01NS109029 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIU, PEIYING · 2018 to 2023
$2.4M
MR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2M
NIBIB NIH HHS P41 EB031771NINDS NIH HHS R01 NS102617NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711NINDS NIH HHS R01 NS109029
6 · The paper itself

Abstract

backgroundHypoxic ischemic encephalopathy (HIE), which is associated with perinatal disruption of cerebral oxygen supply and utilization, is a leading cause of neonatal mortality and severe neurological impairment in childhood. The present study investigated whether key physiological parameters of cerebral oxygen utilization, specifically oxygen extraction fraction (OEF), cerebral blood flow, and cerebral metabolic rate of oxygen (CMRO

methodsIn this case-control study, neonates with HIE and healthy control newborns were enrolled from the Johns Hopkins Children's Center and the Children's Hospital at the University of Maryland Medical Center. The brain's hemodynamic and metabolic parameters of OEF, cerebral blood flow, and CMRO

resultsForty-two neonates with HIE and 54 control neonates were included. Neonates with HIE exhibited lower OEF (control, 31.2±5.2% versus HIE, 28.3±7.3%;

conclusionsThese findings suggest that cerebral oxygen utilization is compromised in neonates with HIE. The physiological parameters of OEF and CMRO

Indexed as

BrainCerebrovascular CirculationHypoxia-Ischemia, BrainOxygenOxygen ConsumptionCase-Control StudiesFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaleOxygenbrain injurieshypoxia-ischemia, braininfant, newbornoxygen consumption

Identifiers

PMID40747539
PMCPMC12483023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.