ReviewArab journal of urology2025
Is varicocele repair justified in infertile men with clinical varicocele, normal conventional semen parameters and elevated sperm DNA fragmentation (SDF)?
Review in Arab journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Areas of Controversy and Confusion in Male Infertility: A Call for Clarity.The world journal of men's health · 2026Article
- Oxidative Stress, Sperm DNA Fragmentation, or Both? Optimizing Test Selection in Male Infertility Evaluation.Antioxidants (Basel, Switzerland) · 2026Review
- Redox-Genomic Crosstalk: Linking Oxidative Stress, Sperm DNA Fragmentation, and Epigenetics in Personalized Management of Male Infertility.Journal of personalized medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varicocele is a prevalent cause of male infertility, with sperm DNA fragmentation (SDF) identified as a key factor. Although varicocele repair (VR) has been associated with improved fertility outcomes, its effectiveness in men who have a palpable varicocele, normal conventional semen analysis, and high SDF levels is still not fully understood. This review summarizes existing evidence regarding the connection between varicocele and SDF, the effect of VR on both SDF and fertility outcomes and focuses on infertile men experiencing these specific conditions. Current literature indicates that VR can significantly improve SDF and reproductive success following surgery, independent of the surgical approach, SDF testing method, or preoperative SDF levels. Nonetheless, additional research is necessary to validate these results and to establish the best management strategies for these individuals. We recommend that organizations engaged in the area of male infertility take into account the significance of SDF testing in the decision-making process concerning VR, particularly for men who present with a palpable varicocele and demonstrate normal findings in conventional semen analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.