Evidence map›Paper›PMID 40747376›Full record

ArticleOncology letters2025

Identification of key ferroptosis-related genes associated with the development of gastric cancer: Prognostic models, molecular mechanisms and potential treatment strategies.

Hui Wang, Hang Chen, Jianjun Liu, Dan Zhang, Da Wang, Minshan Huang, Mengwei Li, Suyu He, Lanqing Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui WangDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Hang ChenDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Jianjun LiuAcademy of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Dan ZhangDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Da WangDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Minshan HuangDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Mengwei LiDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Suyu HeThe Fourth Department of Digestive Disease Center, Suining Central Hospital, Suining, Sichuan 629099, P.R. China.
Lanqing MaDepartment of Gastroenterology, The First Affiliated Hospital, Yunnan Institute of Digestive Disease, Yunnan Clinical Research Center for Digestive Diseases, Kunming Medical University, Kunming, Yunnan 650032, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a novel iron-dependent form of cell death that influences the development and progression of gastric cancer (GC), affecting its growth, invasion and metastasis. However, molecular regulatory mechanisms of ferroptosis in GC remain unclear. The present study aimed to identify key ferroptosis-related genes associated with GC development. Ferroptosis-related genes were collected from FerrDb, a database that collects data on genes and substances that regulate ferroptosis, and the top survival-related genes (including progression-free and overall survival), and differentially expressed genes were identified using data from The Cancer Genome Atlas stomach adenocarcinoma (STAD) samples. Following intersection analysis, least absolute shrinkage and selection operator analysis was performed on 140 screened important genes, and 14 key ferroptosis-related genes in STAD were obtained using Cox regression models. By reviewing the expression of these genes through the Gene Set Cancer Analysis tool and their correlation with survival, the present study analyzed their overall role in STAD. Tumor immunity analysis was performed to identify potential microRNAs (miRs) and drugs targeting key carcinogenic ferroptosis genes in STAD. NADPH oxidase (NOX) 4, NOX5, aldo-keto reductase family 1 member C2, RNA binding motif single stranded interacting protein 1 (RBMS1), GABA type A receptor associated protein like 2 (GABARAPL2), gap junction protein α1 (GJA1), transferrin and hydroxycarboxylic acid receptor 1 were notable risk genes. Additionally, by examining the association between these genes and tumor-infiltrating immune cells, it was discovered that GABARAPL2, GJA1, NOX4 and RBMS1 may influence the immune microenvironment. In total, five miRs [

Indexed as

ferroptosisgastric cancerprognostic modelstomach adenocarcinomatumor immunity

Identifiers

PMID40747376
PMCPMC12308809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.