Evidence map›Paper›PMID 40747365›Full record

ArticleIBRO neuroscience reports2025

Reactive astrocyte-derived neurotoxicity is mitigated by vitronectin in traumatic brain injury mouse model.

Minori Yamashita, Nito Nakahira, Kei Hashimoto, Hirono Kobayashi, Mari Nakashima, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minori YamashitaGraduate School of Humanities and Sciences, Ochanomizu University, Ohtsuka, Bunkyo-ku, Tokyo, Japan.
Nito NakahiraGraduate School of Humanities and Sciences, Ochanomizu University, Ohtsuka, Bunkyo-ku, Tokyo, Japan.
Kei HashimotoInstitute for Human Life Science, Ochanomizu University, Ohtsuka, Bunkyo-ku, Tokyo, Japan.
Hirono KobayashiDepartment of Biology, Faculty of Science, Ochanomizu University, Ohtsuka, Bunkyo-ku, Tokyo, Japan.
Mari NakashimaGraduate School of Humanities and Sciences, Ochanomizu University, Ohtsuka, Bunkyo-ku, Tokyo, Japan.
Hiroko Ikeshima-KataokaKitasato University School of Frontier Engineering, Sagamihara, Kanagawa, Japan.
Yasunori MiyamotoGraduate School of Humanities and Sciences, Ochanomizu University, Ohtsuka, Bunkyo-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitronectin (VN) is an extracellular matrix protein that contributes to brain injury repair by regulating the fibrinolytic system. VN interacts with glial cells to regulate cytokine production. However, it is unclear how VN affects glial dynamics to promote repair of brain injury in a mouse model of traumatic brain injury (TBI). Here, we examined the effect of VN on astrocyte dynamics and neuronal cell death in mouse cerebral cortices after stab wounds. First, we verified that

Indexed as

AstrocyteC3Neuronal cell deathTraumatic brain injuryVitronectin

Identifiers

PMID40747365
PMCPMC12311585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.