ArticleJournal of Taibah University Medical Sciences2025
Histological evaluation of osteogenesis using stem cells from human exfoliated deciduous teeth seeded in polymethylmethacrylate-hydroxyapatite scaffold.
Article in Journal of Taibah University Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Osteogenic Marker Expression after SHED and PMMA-HA Scaffold Application in Alveolar Bone Defects.European journal of dentistry · 2026Article
- Hydroxyapatite-based bone repair biomaterials based on clinical heterogeneity: modification strategies, performance regulation, and personalized repair pathways.Frontiers in bioengineering and biotechnology · 2026Review
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Authors and funding
10 authors.
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Abstract
Objectives: Alveolar bone defect is a challenge in dentistry. Stem cells from human exfoliated deciduous teeth (SHED) seeded in polymethylmethacrylate (PMMA)/hydroxyapatite (HA) have been proposed as a bone defect biomaterial to facilitate bone regeneration. However, the potential of using a new biomaterial scaffold for osteogenesis needs to be tested in vivo before clinical use. Thus, in this study, the various histological indicators associated with SHED-seeded PMMA/HA were analyzed in terms of osteogenesis and bone regeneration. Materials and methods: Wistar rats were treated with SHED-seeded PMMA/HA as an immediate graft following extraction of their upper right first incisors. Defects were randomly allocated to three groups, each containing 24 male Wistar rats, according to the biomaterials used for treatment: (1) no treatment (negative control); (2) defects treated with PMMA/HA; and (3) defects treated with SHED-seeded PMMA/HA. Animals were sacrificed on days 14 and 28 for histological evaluation. Results: Alveolar bone defects treated with SHED-seeded PMMA/HA had significantly higher levels of macrophages, fibroblasts, lymphocytes, plasma cells, osteoblasts, and woven bone compared with PMMA/HA treatment alone ( Conclusion: Histological findings showed that SHED-seeded PMMA/HA was effective in promoting osteogenesis and facilitating bone regeneration, which is the main requirement when considering an alternate material for the repair of alveolar bone defects.
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