ArticleResuscitation plus2025
Changes in T-lymphocyte subsets and natural killer cells of patients after out-of-hospital cardiac arrest and resuscitation: a retrospective study.
Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Purpose: Immune dysregulation in patients resuscitated from out-of-hospital cardiac arrest (OHCA) represents a major clinical issue. This study aimed to analyze the changes in T-lymphocyte subsets and natural killer (NK) cells after the return of spontaneous circulation. Methods: A total of 183 OHCA patients were enrolled in this study. The counts and percentages of T-lymphocyte subsets and NK cells were retrospectively collected. These patients were stratified into four groups based on the time interval from OHCA to sample collection: ≤12 h, 12-24 h, 24-48 h, and >48 h. The outcome measures were survivors and neurological function as defined by the Cerebral Performance Category (CPC) scale at discharge. Results: After ROSC, the counts of CD3+ T cells, CD4+ T cells, CD8+ T cells, and NK cells were all lower. The percentage of CD4+ T cells increased over time (≤12 h vs 12-24 h vs 24-48 h vs >48 h: 28.6 ± 11.5 % vs. 37.9 ± 15.0 % vs. 39.0 ± 11.6 % vs. 40.9 ± 15.0 %, Conclusions: After OHCA, T-lymphocyte subsets and NK cells were present at low levels, and the temporal variation trends of different lymphocyte subsets differed.
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