ArticleWorld journal of hepatology2025
Autoimmune hepatitis with syncytial giant cells in chronic lymphocytic leukemia: A case report and literature review.
Article in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Acute Acalculous Cholecystitis Mimicry: Symptomatic Hepatic Infiltration From Chronic Lymphocytic Leukemia Presenting as Cholestatic Liver Injury.ACG case reports journal · 2026Article
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10 authors.
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Abstract
backgroundHepatic manifestations in chronic lymphocytic leukemia (CLL) are common: Elevation of liver enzymes frequently occurs, and differential diagnosis is often challenging. Liver infiltration by leukemic cells, primary and secondary hepatic malignancies, drug-induced hepatotoxicity, immunological disorders, and infections have been reported. Nevertheless, syncytial giant cell hepatitis (GCH) as a manifestation of autoimmune hepatitis in patients with CLL is an extremely rare condition, currently reported only in anecdotal cases. CASE SUMMARY: Here, we report the case of a 62-year-old Caucasian woman affected by CLL, who developed GCH with peculiar histopathological features. The patient was evaluated for abnormal liver test results. Liver histology revealed significant inflammatory lymphomononuclear infiltrates with a plasma cell component, widespread syncytial changes in the hepatocytes with gigantocellular features, hepatocyte rosettes, and the typical feature of emperipolesis, consistent with a diagnosis of GCH. The patient was treated with corticosteroids and mycophenolate mofetil, resulting in a complete biochemical response.
conclusionEarly histological diagnosis of GCH is crucial in patients with CLL, with mycophenolate mofetil representing a promising treatment option.
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