ReviewCureus2025
Exploring the Immune System's Role in Endometriosis: Insights Into Pathogenesis, Pain, and Treatment.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Deep immune profiling of endometrial and peripheral blood cells in endometriosis.Human reproduction (Oxford, England) · 2026Observational
- Targeting the Immune Network in Endometriosis: A Comprehensive Review of Pathogenesis, Immunomodulation, and Emerging Therapies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Is Recurrent Endometriosis a Reprogrammed Disease? Molecular Persistence Beyond Surgical Clearance.Cells · 2026Review
- Epigenetic Landscape of Female Infertility: An Integrated Bioinformatics Perspective on DNA Methylation, MicroRNAs, and Gene Regulatory Networks Across PCOS, Endometriosis, and Diminished Ovarian Reserve.International journal of molecular sciences · 2026Article
- Review
- Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy.International journal of molecular sciences · 2026Review
- Omega-3 polyunsaturated fatty acid intake and pain, inflammatory cytokines, and quality of life in endometriosis.Frontiers in nutrition · 2026Article
- Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis is a common gynecological condition that usually affects women during their reproductive years. The main goal of this narrative review is to understand the role of the innate and adaptive immune system in the pathogenesis of endometriosis and to explore ways to diagnose and treat endometriosis effectively. Methodology: A comprehensive literature search was conducted across PubMed, EMBASE, Cochrane, and Scopus. Full-text articles in English published between January 2019 and January 2025 were included in this review. Two independent reviewers screened titles and abstracts using preset inclusion and exclusion criteria, as well as relevant keywords related to endometriosis, immune responses, and chronic pain. Of 6,728 initially identified studies, 53 met the inclusion criteria after applying exclusion parameters. Recent papers shed light on the role of the immune system in the pathogenesis of endometriosis. The dysregulation of immune system cells, such as macrophages, natural killer cells, neutrophils, dendritic cells, T cells, and B cells, contributes to the pathogenesis of endometriosis by enhancing the development and progression of endometriosis lesions, thereby creating an inflammatory environment. The presence of the inflammatory environment not only supports the survival and growth of the ectopic endometrial lesion but also plays a vital role in the pain associated with it. Endometriosis is a disease characterized by the presence of ectopic endometrial-like tissue outside the uterine cavity. It is believed that this ectopic endometrial tissue is a result of an interplay between hormonal, immune, and environmental factors. To this day, the gold standard for diagnosing endometriosis is through laparoscopic surgery, and there is no long-lasting effective medical treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.