Evidence map›Paper›PMID 40746958›Full record

ArticleFrontiers in cellular and infection microbiology2025

Biofilm-mediated resistance to berberine in

Yingfang Wang, Ruinan Zhang, Pengfei Wang, Wenlu Zhang, Zhongjie Li, Xinyue Pang, Fangfang Huang, Sensen Wang, Xingnuo Liu, He Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Antimicrobial Peptide CRAMP-34 EradicatesAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingfang Wang *Henan University of Science and Technology, School of Basic Medical Science and Forensic Medicine, Luoyang, Henan, China.
Ruinan Zhang *Henan University of Science and Technology, School of Basic Medical Science and Forensic Medicine, Luoyang, Henan, China.
Pengfei WangHenan University of Science and Technology, School of Hospital, Luoyang, Henan, China.
Wenlu ZhangHenan University of Science and Technology, School of Basic Medical Science and Forensic Medicine, Luoyang, Henan, China.
Zhongjie LiHenan University of Science and Technology, School of Basic Medical Science and Forensic Medicine, Luoyang, Henan, China.
Xinyue PangHenan University of Science and Technology, School of Medical Technology and Engineering, Luoyang, Henan, China.
Fangfang HuangHenan University of Science and Technology, School of Basic Medical Science and Forensic Medicine, Luoyang, Henan, China.
Sensen WangHenan University of Science and Technology, School of Basic Medical Science and Forensic Medicine, Luoyang, Henan, China.
Xingnuo LiuHenan University of Science and Technology, School of Basic Medical Science and Forensic Medicine, Luoyang, Henan, China.
He ZhangHenan University of Science and Technology, School of Affiliated First Hospital, Luoyang, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the mechanism of biofilm-mediated resistance to berberine in Methods: The resistance of berberine against Results: The MIC after berberine induction was more than 32 times than the MIC before induction. the biofilm was significantly increased at 24, 48 and 72 hours ( Conclusion: Berberine might increase biofilm formation by inducing the expression of

Indexed as

Anti-Bacterial AgentsBerberineBiofilmsDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsGene Expression ProfilingGene Expression Regulation, BacterialMicrobial Sensitivity TestsReal-Time Polymerase Chain ReactionRNA, MessengerAnti-Bacterial AgentsBerberineEscherichia coli ProteinsRNA, MessengerberberinebiofilmcsgD genedrug resistance-related genesEscherichia coli

Identifiers

PMID40746958
PMCPMC12310584

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.