Evidence map›Paper›PMID 40746956›Full record

ArticleFrontiers in cellular and infection microbiology2025

Intramuscular iron supplementation enhances intestinal barrier function in weaned piglets challenged with enterotoxigenic

Chenying Tian, Xiaofeng Zhang, Yecheng Xu, Linfeng Miao, Jing Zhao, Qingqing Xiong, Yuhui Zhang, Shouchuan Jiang, Yu Han, Huahua Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Strain-resolved biology ofFrontiers in veterinary science · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenying Tian *Key Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Xiaofeng Zhang *Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Yecheng XuKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Linfeng MiaoKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Jing ZhaoKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Qingqing XiongKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Yuhui ZhangKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Shouchuan JiangKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Yu HanKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Huahua DuKey Laboratory of Nutrition and Breeding for High-quality Animal Products of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Since iron is an essential mineral for both host and microbial communities, how to scientifically replenish the iron in the context of bacterial infection has become a critical issue. The aim of this study was to compare the influence of intramuscular and oral iron supplementation on the progression of bacterial infection. Methods: Weaned piglets served as an experimental model for iron supplementation following enterotoxigenic Results: Intramuscular iron supplementation alleviated the clinical symptoms of bacterial infection, decreasing the diarrhea rate by 53% and mitigating the inflammatory response with lower serum levels of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8. Compared to oral iron supplementation, intramuscular iron supplementation significantly mitigated the intestinal damage caused by ETEC K88 infection by increasing the ratio of villus length to crypt depth, and repairing epithelial tight junction. Furthermore, intramuscular iron supplementation also protected the function of intestinal goblet cells and improved iron metabolism of infected piglets. Conclusion: Intramuscular iron supplementation is more effective during infection than oral iron supplementation.

Indexed as

Dietary SupplementsEnterotoxigenic Escherichia coliEscherichia coli InfectionsIntestinal MucosaIronSwine DiseasesAdministration, OralAnimalsCytokinesDiarrheaDisease Models, AnimalGastrointestinal MicrobiomeInjections, IntramuscularIntestinal Barrier FunctionSwineWeaningCytokinesIrondiarrheaETEC K88intestinal barrier functionintramuscular iron supplementationoral iron supplementationweaned piglets

Identifiers

PMID40746956
PMCPMC12310581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.