ReviewHealth science reports2025
Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review.
Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Influence of vitamin D supplementation on ovarian reserve as reflected by anti-Müllerian hormone levels: a meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Regular levels of reactive oxygen species (ROS) are essential for regulating the growth and activity of ovarian follicles, very high levels can lead to accelerated oxidative stress, which in turn causes premature ovarian insufficiency (POI) and reproductive dysfunction. Objectives: This systematic review aimed to assess the impact of supplementing with vitamins D, E, and selenium on specific markers related to ovarian reserve. Methods: Electronic websites, including Web of Science, PubMed, Scopus, ScienceDirect, ProQuest, Cochrane, SAGE, Springer, and Google Scholar were searched for published studies from March 2012 to December 2024. Of the 2067 references identified in the initial search, in total, ten observational studies, one randomized control trial (RCT), and one quasi-experimental study that assessed the association between antioxidant vitamins (D, E, SE) and POI were included in this systematic review. Results: A total of 521 women were included in all studies. All studies showed an overall association between serum levels of vitamins D, E, and selenium (SE) on POI and ovarian reserve markers. However, not all studies found this association. Conclusion: This review showed that a lack of vitamin D, E, and SE may affect POI. Supplementation can elevate AMH levels while simultaneously reducing FSH hormone. Given the increasing trend of POI, these findings could be promising and act as a preventive or curative approach for POI, if documented in further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.