ArticleOncology research2025
Cell cycle and HIF-1 related gene expression alteration in thyroid cell lines under microgravity.
Article in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multimodal spectrum of approach in poorly differentiated thyroid carcinoma (an updated analysis).Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With growing interest in space exploration, understanding microgravity's impact on human health is essential. This study aims to investigate gene expression changes and migration and invasion potential in five thyroid-related cell lines cultured under simulated microgravity. Methods: Five thyroid-related cell lines-normal thyrocytes (Nthy-ori 3-1), papillary thyroid cancer (PTC) cells (SNU-790, TPC-1), poorly differentiated thyroid cancer cell (BCPAP), and anaplastic thyroid cancer cell (SNU-80)-were cultured under simulated microgravity (10 Results: DEG analysis under simulated microgravity revealed distinct gene expression profiles by gravity condition, with 2980 DEGs in SNU-790, 1033 in BCPAP, 562 in TPC-1, 477 in Nthy-ori 3-1, and 246 in SNU-80, as confirmed by hierarchical clustering. In PTC cell lines (SNU-790, TPC-1), G2-M phase-related genes were upregulated. In non-PTC cell lines (BCPAP, SNU-80), genes associated with innate immune response, Toll-like receptor signaling, were upregulated, whereas Hypoxia-Inducible Factor 1-alpha (HIF-1α) signaling-related genes were downregulated. Additionally, under simulated microgravity, significant migration was observed in SNU-790 (3 × 10 Conclusion: This study comprehensively evaluates the effects of simulated microgravity using a diverse panel of thyroid-related cell lines. These findings provide valuable insight into how microgravity could influence cancer biology, emphasizing the importance of further research on cancer behavior in space environments and its implications for human health during long-term space missions.
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