Evidence map›Paper›PMID 40746888›Full record

ArticleOncology research2025

Identifying ATP-Binding Cassette Member B5 as a New Biomarker for Oral Squamous Cell Carcinoma.

Li Yu, Xiaoyan Zhang, Yan Feng, Xinyue Liao, Tiejun Zhou, Hang Si, Yun Feng, Decai Wang, Yongxian Lai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li YuOral & Maxillofacial Reconstruction, Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.
Xiaoyan ZhangOral & Maxillofacial Reconstruction, Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.
Yan FengOral & Maxillofacial Reconstruction, Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.
Xinyue LiaoOral & Maxillofacial Reconstruction, Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.
Tiejun ZhouDepartment of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Hang SiOral & Maxillofacial Reconstruction, Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.
Yun FengOral & Maxillofacial Reconstruction, Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.
Decai WangDepartment of Urology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, 621000, China.
Yongxian LaiOral & Maxillofacial Reconstruction, Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunocytochemistry (ICC) were performed to examine the level of ABCB5 in OSCC (CAL27 and HSC-3) and human oral keratinocyte (HOK). ABCB5 was knocked down in CAL27 cells using ABCB5-specific small interfering RNA (ABCB5 siRNA), and its contribution to migration, invasion, and epithelial-mesenchymal transition (EMT), a process by which epithelial cells lose their tight junction and acquire an increased migratory and invasive phenotype resembling that of mesenchymal cells, were evaluated by three-dimension and transwell migration and invasion assays, qRT-PCR and ICC. An Results: ABCB5 was significantly upregulated in CAL27 and HSC-3 cells as compared to HOK. Knockdown of ABCB5 significantly reduced the number of migrated and invaded CAL27 cells, accompanied by the significantly increased E-cadherin and decreased Vimentin and N-cadherin under Transforming growth factor β (TGF-β) treatment. Conclusion: ABCB5 promotes the migration, invasion, and EMT of OSCC. ABCB5 might be a new biomarker and potential therapeutic target for OSCC.

Indexed as

ATP Binding Cassette Transporter, Subfamily BBiomarkers, TumorCarcinoma, Squamous CellMouth Neoplasms4-Nitroquinoline-1-oxideAnimalsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMaleMiceSquamous Cell Carcinoma of Head and Neck4-Nitroquinoline-1-oxideABCB5 protein, humanATP Binding Cassette Transporter, Subfamily BBiomarkers, TumorATP-binding cassette subfamily B member 5 (ABCB5)epithelial-mesenchymal transition (EMT)invasionmigrationOral squamous cell carcinoma (OSCC)

Identifiers

PMID40746888
PMCPMC12308245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.