Evidence map›Paper›PMID 40746872›Full record

ArticleTribology letters2025

Pro-Inflammatory Response to Macrotextured Silicone Implant Wear Debris.

Dixon J Atkins, Ann E Rogers, Kathryn E Shaffer, Ian Moore, Wyatt D Miller, Meghan A Morrissey, Angela A Pitenis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tribology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dixon J AtkinsInterdisciplinary Program in Quantitative Biosciences, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Ann E RogersMolecular Cellular and Developmental Biology Department, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Kathryn E ShafferMaterials Department, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Ian MooreMaterials Research Laboratory, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Wyatt D MillerInterdisciplinary Program in Quantitative Biosciences, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Meghan A MorrisseyMolecular Cellular and Developmental Biology Department, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Angela A PitenisMaterials Department, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

Funding

Predoctoral Training Program in Quantitative MechanobiologyT32GM141846 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Siddharth Subhas Dey, Beth L Pruitt · 2021 to 2026
$1.9M
Signal Integration during PhagocytosisR35GM146935 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Meghan A Morrissey · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM146935NIGMS NIH HHS T32 GM141846
6 · The paper itself

Abstract

Macrotextured silicone breast implants are associated with several complications, ranging from seromas and hematomas to the formation of a rare type of lymphoma, known as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The presence of silicone wear debris has been detected within the peri-implant region and fibrotic capsule and histological analyses reveal inflammatory cells surrounding debris particles. However, it is unclear how these debris particles are generated and released from macrotextured implant surfaces, and whether wear debris generation is related to implant stiffness. In this study, we created an accelerated implant aging model to investigate the formation of silicone wear debris produced from self-mated ("shell-shell") tribological interactions. We created implant-like silicone elastomers from polydimethylsiloxane (PDMS) using Sylgard 184 base:curing agent (10:1, 12:1, and 16:1) and quantified their mechanical properties (

Indexed as

BiotribologyBreast implantsFrictionInflammationMacrophagesSilicone elastomers

Identifiers

PMID40746872
PMCPMC12313313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.