Evidence map›Paper›PMID 40746870›Full record

ArticleAdvances in ophthalmology practice and research

Causal associations between smoking and ocular diseases: a Mendelian randomization study.

Zhaohao Huang, Junjie Chen, Lu Shi, Jun Huang

Abstract read
In one paragraph

Article in Advances in ophthalmology practice and research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Bioinformatics analysis identifiesTranslational cancer research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhaohao HuangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Junjie ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Lu ShiOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jun HuangOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To explore the causal associations between smoking and ocular diseases using Mendelian randomization (MR). Methods: A two-sample Mendelian randomization (MR) analysis based on publicly.available genome-wide association studies were employed to infer the causal relationship. The effect estimates were calculated using the random-effects inverse-variance-weighted method. Results: Genetically predicted smoking was positively associated with cataract [Odds ratio (OR) ​= ​1.14, 95% confidence interval (CI): ​1.01-1.29; Conclusions: Smoking may increase the risks of cataract, w-AMD, diabetic retinopathy, disorders of optic nerve and visual pathways. And smoking may decrease the risk of myopia.

Indexed as

CataractCausal associationDiabetic retinopathyMendelian randomizationMyopiaSmokingw−AMD

Identifiers

PMID40746870
PMCPMC12311542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.