Evidence map›Paper›PMID 40746864›Full record

ArticleFASEB bioAdvances2025

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle.

Alexander Ahn, Jeongjin J Kim, Aaron L Slusher, Jeffrey Y Ying, Eric Y Zhang, Andrew T Ludlow

Abstract read
In one paragraph

Article in FASEB bioAdvances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander AhnSchool of Kinesiology University of Michigan Ann Arbor Michigan USA.ORCID https://orcid.org/0009-0009-7865-2061
Jeongjin J KimSchool of Kinesiology University of Michigan Ann Arbor Michigan USA.ORCID https://orcid.org/0000-0002-6959-8544
Aaron L SlusherSchool of Kinesiology University of Michigan Ann Arbor Michigan USA.ORCID https://orcid.org/0000-0003-2082-4827
Jeffrey Y YingSchool of Kinesiology University of Michigan Ann Arbor Michigan USA.
Eric Y ZhangSchool of Kinesiology University of Michigan Ann Arbor Michigan USA.ORCID https://orcid.org/0009-0000-7975-0303
Andrew T LudlowSchool of Kinesiology University of Michigan Ann Arbor Michigan USA.ORCID https://orcid.org/0000-0003-0423-4800

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Manipulating hTERT splicing in lung cancer cells.R00CA197672 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUDLOW, ANDREW TODD · 2017 to 2019
$738k
NCI NIH HHS R00 CA197672NIAMS NIH HHS P30 AR069620
6 · The paper itself

Abstract

Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome. Acute endurance exercise appears to transiently perturb AS in skeletal muscle, but transcriptome-wide responses are not well defined. We aimed to better understand differential AS (DAS) and differential isoform expression (DIE) in skeletal muscle by comparing short-read (SRS) and long-read RNA sequencing (LRS) data. Publicly accessible SRS of clinical exercise studies were extracted from the Gene Expression Omnibus. Oxford Nanopore LRS was performed on mouse gastrocnemius before and following treadmill exercise (30 m running,

Indexed as

alternative RNA splicingendurance exerciseRNA‐binding proteinsskeletal musclesplicing factors

Identifiers

PMID40746864
PMCPMC12312519

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.