ArticleCureus2025
Beyond the Flare: A Case of Systemic Lupus Erythematosus Complicated by Hemophagocytic Lymphohistiocytosis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Cytomegalovirus-induced hemophagocytic lymphohistiocytosis revealing systemic lupus erythematosus: a case report.Annals of medicine and surgery (2012) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially fatal hyperinflammatory syndrome marked by excessive immune activation, cytokine storm, multiorgan failure, and high mortality. Systemic lupus erythematosus (SLE) is considered to be one of the triggers. SLE-associated HLH is especially challenging to diagnose and manage, as it can mimic lupus flares. We describe a 30‑year‑old woman with SLE who developed secondary HLH. Initially thought to have an SLE flare, she rapidly deteriorated with multiorgan dysfunction. The diagnosis of HLH was confirmed using the HLH-2004 criteria and a significantly elevated H-score. Despite intensive treatment with corticosteroids and immunosuppressive agents, the patient ultimately died from HLH-related complications. This case highlights the critical need for early recognition and prompt differentiation of HLH from lupus flares in SLE patients. Timely, targeted therapy is essential to improve outcomes in this high-risk group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.