Evidence map›Paper›PMID 40746692›Full record

ArticleFrontiers in public health2025

Effects of agricultural or gardening physical activity on cardiovascular disease and dementia-related markers via arterial stiffness, cognitive function, and cerebral white matter status: results from cross-sectional and interventional studies.

Masato Nishiwaki, Seiya Takada, Shotaro Otsuka, Hyuma Makizako, Harutoshi Sakakima, Naoto Shiomi, Satomi Ooba, Naoyuki Matsumoto, Kiyoshi Kikuchi

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Masato Nishiwaki *Faculty of Engineering, Osaka Institute of Technology, Osaka, Japan.
Seiya TakadaDepartment of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Shotaro OtsukaFaculty of Welfare and Health Science, Oita University, Dannoharu, Oita, Japan.
Hyuma MakizakoDepartment of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
Harutoshi SakakimaDepartment of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
Naoto ShiomiDepartment of Critical and Intensive Care Medicine, Shiga University of Medical Science, Otsu, Japan.
Satomi OobaOoba Clinic for Neurosurgery and Headache, Oita, Japan.
Naoyuki MatsumotoFaculty of Environmental Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan.
Kiyoshi Kikuchi *Division of Brain Science, Department of Physiology, Kurume University School of Medicine, Kurume, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Agricultural or gardening physical activity (AGPA) offers potential as a simple strategy to improve cardiovascular disease and dementia-related markers; however, the actual preventive effects remain unclear. Our objective was to investigate AGPA regarding related markers of cardiovascular disease and dementia using cross-sectional and interventional approaches. Methods and results: In Study 1, community-based older individuals were assessed, and 30 individuals who performed AGPA (AG group) and 30 1:1 age-, sex-, and objective activity-matched controls were cross-sectionally compared (mean age, 75 ± 6 y). Arterial stiffness (pulse wave velocity) was lower and hand-finger dexterity (pegboard test) was higher in the AG vs. control groups. The interventional results of Study 2 (secondary analysis of a randomized controlled trial) confirmed that consistent AGPA might regress white matter hyperintensities in older individuals. Conclusion: Our findings suggest that consistent AGPA Secondary analysis of clinical trials study 2: Study for Decreasing Depressive Symptoms and Increasing Memory Performance in the older adults (Trial registration number UMIN000018547, Date of registration 2015/08/07), URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000021462.

Indexed as

Cardiovascular DiseasesCognitionDementiaExerciseGardeningVascular StiffnessWhite MatterAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleHumansMaleBiomarkersagriculturecardiovascular diseasescognitionvascular stiffnesswhite matter

Identifiers

PMID40746692
PMCPMC12311633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.