ArticleJournal of multidisciplinary healthcare2025
The Gut Microbiota and the Nerve-Bone Axis: Insights from a Mendelian Randomization and Mediation Analysis.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly.Current osteoporosis reports · 2026Review
- Research progress on the mechanisms by which gut microbiota dysbiosis remodels the bone marrow neuroimmune microenvironment to drive age-related osteoporosis.Frontiers in immunology · 2026Review
- The potential role and research progress of the gut microbiota-NGF axis in postmenopausal bone homeostasis imbalance.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aims to explore the interconnections among gut microbiota, autonomic nervous system (ANS), and bone through the proposed gut-nerve-bone axis using Mendelian randomization (MR) mediation analysis. Methods: Genetic variants associated with gut microbiota were extracted from the MiBioGen consortium. Summary statistics for bone mineral density (BMD) were derived from a UK Biobank genome-wide association study dataset. We used heart rate variability (HRV) to represent the activity of ANS in the MR analysis. Initially, we employed a two-sample MR approach to evaluate the causal impact of gut microbiota on BMD. Subsequently, we used an additional mediation analysis to assess the effect of HRV on these associations, and sensitivity analysis was used to ensure the reliability of our results. Results: Conclusion: In summary, the present research supports a genetic correlation among gut microbiota, ANS, and BMD, which reinforces the concept of a gut-nerve-bone axis. Notably, the interplay between gut microbiota and BMD may be mediated by ANS. Additional mechanistic and clinical investigations are required to corroborate our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.