Evidence map›Paper›PMID 40746620›Full record

ReviewJournal of diabetes and metabolic disorders2025

The multifunctional role of bovine colostrum in managing diabetes: clinical insights and potential therapeutic effects.

Gilda Aiello, Yalçın Mert Yalçıntaş, Diego Campaci, Mauro Lombardo, Fares M S Muthanna, Caterina Conte, Sercan Karav, Gianluca Tripodi, Sara Baldelli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gilda Aiello *Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Canakkale, 17000 Türkiye.
Yalçın Mert Yalçıntaş *Department for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, Rome, 00166 Italy.
Diego CampaciDepartment for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, Rome, 00166 Italy.
Mauro LombardoDepartment for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, Rome, 00166 Italy.
Fares M S MuthannaDepartment of Pharmacy, Faculty of Medicine and Health Sciences, University of Science and Technology, Aden, Yemen.
Caterina ConteDepartment for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, Rome, 00166 Italy.
Sercan KaravDepartment of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Canakkale, 17000 Türkiye.
Gianluca TripodiDepartment for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, Rome, 00166 Italy.
Sara BaldelliDepartment for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, Rome, 00166 Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a global metabolic disorder characterised by insulin resistance or insufficient insulin production, leading to chronic hyperglycemia and severe complications. Although pharmacological treatments exist, there is a growing interest in complementary therapies to improve glycaemic control and attenuate disease progression. Bovine colostrum, a nutrient-rich secretion produced after parturition, contains bioactive compounds such as insulin-like growth factor-1 (IGF-1), lactoferrin, cytokines and immunoglobulins, which have potential therapeutic effects on diabetes. The aim of the review is to report on the various molecular mechanisms through which bovine colostrum is involved in diabetes management. The review analyzes, through clinical studies and potential therapeutic effects, the influence of colostrum on glucose metabolism, insulin sensibility, oxidative stress, and inflammatory processes. Preclinical and clinical evidence suggests that bovine colostrum supplementation can lower blood glucose levels, improve lipid profiles and enhance immune modulation in type 1 and type 2 diabetes. In addition, its role in healing wounds and injuries has been demonstrated in a number of studies that have demonstrated the efficacy of bovine colostrum. Furthermore, its role in wound healing and regulation of the gut microbiota highlights its potential as an adjunctive therapy for diabetes management. Further research is needed to standardise formulations and determine optimal dosages for clinical applications. Graphical Abstract:

Indexed as

Bioactive peptidesBovine colostrumDiabetesGlycemic controlInflammationInsulin resistance

Identifiers

PMID40746620
PMCPMC12307866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.