ReviewFrontiers in immunology2025
Emerging B and plasma cell-targeting immune therapies in idiopathic inflammatory myopathies.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Animal Models of Idiopathic Inflammatory Myopathies: Bridging Mechanistic Insights and Clinical Translation.International journal of molecular sciences · 2026Review
- Emerging therapies in idiopathic inflammatory myopathies.Journal of neuromuscular diseases · 2026Review
- Review
- High-plex spatial protein profiling of skeletal muscle biopsies in inflammatory myopathies using the MACSima™ imaging platform: A pilot study.Acta neuropathologica communications · 2026Article
- Targeted Therapy for Idiopathic Inflammatory Myopathy.Journal of cachexia, sarcopenia and muscle · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoantibodies play a crucial role in the diagnosis and clinical characterization of idiopathic inflammatory myopathies (IIM). These antibodies are categorized into myositis-specific autoantibodies (MSAs), which are unique to IIM, and myositis-associated autoantibodies (MAAs), which can be seen with other autoimmune diseases. Both plasmablasts and plasma cells contribute to the production of these autoantibodies. Current B cell-targeted therapies, such as rituximab, have shown promise in refractory IIM, although their limitations - particularly in targeting plasmablasts and plasma cells - highlight the need for alternative agents with greater efficacy. This review discusses the evolving landscape of B cell and plasma cell-targeted immunotherapies in IIM, including next-generation anti-CD20 antibodies, BAFF inhibition, anti-CD19 CAR-T cells, BCMA-targeted therapies, and anti-CD38 antibodies. Most studies on the use of these novel treatment strategies in IIM have reported positive outcomes, although the number of patients treated is small. While these therapies represent a paradigm shift, further randomized clinical trials are needed to identify optimal strategies for IIM management and establish long-term safety and efficacy.
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Registered trials
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