ReviewFrontiers in immunology2025
Uncovering a new mechanism of ischemic stroke: a study of the association between γδ T cells and immunoinflammation.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Temporal Vulnerability of the Blood-Brain Interface in Stroke: Molecular Mechanisms of Circadian Dynamics, Inflammation, and Aging.International journal of molecular sciences · 2026Review
- Revolutionizing stroke therapy: microfluidic brain chips as a translational bridge.Annals of medicine and surgery (2012) · 2026Article
- Decreased Anti-inflammatory IL-2 and IL-10 and Increased Mononuclear Cell Tissue Factor Correlate with Stroke Severity: Do Anti-inflammatory Cytokines Modulate Thrombosis?CNS & neurological disorders drug targets · 2026Article
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Authors and funding
5 authors.
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Abstract
Ischemic stroke, characterized by high clinical mortality and poor prognosis, has been prioritized by the World Health Organization (WHO) for reducing the burden of non-communicable diseases. However, the pathogenesis of ischemic stroke remains complex and poorly understood. Recent studies have revealed the infiltration of γδ T cells within ischemic stroke lesions, accompanied by the upregulation of IL-17, IL-23, and other inflammatory cytokines, suggesting their involvement in the stroke's pathological process. Literature indicates that γδ T cells are recruited to the lesion site by microglia-derived chemokines and subsequently infiltrate the damaged brain tissue. This review summarizes current knowledge on the precise mechanisms underlying γδ T cell activation, migration, and ensuing immune-inflammatory responses in neuroinflammation, as well as their role in the progression of ischemic stroke. It further discusses the therapeutic potential of targeting γδ T cells to modulate neuroinflammation for ischemic stroke treatment, thereby offering novel therapeutic targets for managing neuroinflammation in this condition.
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