Evidence map›Paper›PMID 40746501›Full record

ArticleJCEM case reports2025

Well-Differentiated Lung Neuroendocrine Tumor Masquerading as Metastatic Medullary Thyroid Cancer.

Marc Stezzi, Marcia Brose, Sarah W Gordon, Charalambos Solomides, Madalina Tuluc, Jeffrey Miller

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marc StezziDepartment of Endocrinology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.ORCID https://orcid.org/0009-0004-7236-2243
Marcia BroseDepartment of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Sarah W GordonDepartment of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Charalambos SolomidesDepartment of Cytopathology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Madalina TulucDepartment of Cytopathology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Jeffrey MillerDepartment of Endocrinology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Typical carcinoid tumors, or low-grade neuroendocrine tumors (NETs), are a rare class of neoplasms that share histopathological characteristics with other NETs like medullary thyroid cancer (MTC). Here, we report an 85-year-old woman with a history of left hemithyroidectomy in the 1980s (pathology not available) and right-sided multinodular goiter biopsied as benign, initially misdiagnosed with metastatic MTC based on lung nodule biopsy staining for calcitonin. The lung nodule was surgically removed and shown to be a well-differentiated lung NET. This case demonstrates the diagnostic challenges of integrating cytopathological findings, such as calcitonin staining, with the overall clinical scenario to arrive at an accurate diagnosis.

Indexed as

calcitoninfine-needle aspirationmedullary thyroid cancerneuroendocrine tumortypical carcinoid tumor

Identifiers

PMID40746501
PMCPMC12311422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.