ArticleBiomedical reports2025
Analysis of cell turnover in the macula densa through the normal aging process.
Article in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Review
- Immunohistochemical Characterization of the Immune Response in Chronic Endometritis Caused byDiagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kidney undergoes changes during the lifespan of an individual, resulting in increased susceptibility to renal diseases in the elderly. The macula densa (MD) controls basic kidney functions, which deteriorate with aging. The present study for the first time, to the best of our knowledge, analyzed the relationship between cell proliferation and apoptosis (cell turnover) in the MD of mice through the normal aging process. Kidney specimens from CD1 mice aged 2, 6, 12, 18 or 24 months were fixed in neutral-buffered formalin and embedded in paraffin. Tissue sections were immunostained to analyze cell proliferation, subjected to a TUNEL assay to evaluate apoptosis, or stained with hematoxylin and eosin to determine total cell number. A markedly dynamic cell turnover pattern was observed in the MD throughout the aging process, in which, when the number of proliferating cells increased, the number of apoptotic cells decreased and vice versa. However, there were no significant differences in the total cell number among the ages analyzed. Thus, other mechanisms may be involved in the deterioration of renal functions regulated by the MD in elderly people. Further research is required to determine these mechanisms, which could be the target of therapeutic strategies against age-related kidney diseases in the future.
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