ArticleJournal of conservative dentistry and endodontics2025
Concurrent infusion of glutathione, tranexamic acid, and Vitamin C as oral mesotherapeutic agents for management of gingival hyperpigmentation: A case series.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Chronocosmetic Approach to Treating Signs of Aging with Glutathione.Life (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gingival melanin pigmentation, although physiologically benign, often poses a significant esthetic concern, particularly in individuals with high smile lines. This case series aimed to assess the clinical outcomes of mesotherapy using a combination of Vitamin C, tranexamic acid, and glutathione as a minimally invasive approach to gingival depigmentation. Two systemically healthy patients exhibiting diffuse melanin pigmentation in the anterior maxillary gingiva were managed with intramucosal injections administered at weekly intervals over three sessions. Clinical evaluation was performed using the Dummett and Gupta Oral Pigmentation Index at baseline and at a 3-month follow-up. Both cases demonstrated a marked reduction in gingival pigmentation with satisfactory esthetic improvement and no reported adverse effects or recurrence. These preliminary findings suggest that mesotherapy with a synergistic combination of antioxidant and depigmenting agents may offer a viable, conservative alternative to conventional depigmentation techniques.
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